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Process server Dale Denton (Seth Rogen) has a grudging business relationship with the laconic Saul Silver (James Franco), deigning to visit only to purchase Saul's primo product -- a rare new strain of pot called Pineapple Express.
But when Dale becomes the only witness to a murder by a crooked cop (Rosie Perez) and the city's most dangerous drug lord (Gary Cole), he panics and dumps the Pineapple Express at the scene. When it's traced back to him, Dale and Saul run for their lives... and they quickly discover that they're not just suffering from weed-fueled paranoia.
If they survive, these two just might become real friends. All aboard the Pineapple Express.