A pampered Beverly Hills Chihuahua named Chloe (voice of Drew Barrymore) finds herself accidentally lost in the mean streets of Mexico without a day spa or Rodeo Drive boutique anywhere in sight. Now alone for the first time in her spoiled life, she must rely on some unexpected new friends--including a street-hardened German Shepherd named Delgado (voice of Andy Garcia) and an amorous pup named Papi (voice of George Lopez)--to lend her a paw and help her to find her inner strength on their incredible journey back home.