Jerry Shaw (Shia LaBeouf) and Rachel Holloman (Michelle Monaghan) are two strangers thrown together by a mysterious phone call from a woman they have never met. Threatening their lives and family, she pushes Jerry and Rachel into a series of increasingly dangerous situations -- using the technology of everyday life to track and control their every move. As the situation escalates, these two ordinary people become the country's most wanted fugitives, who must work together to discover what is really happening -- and more importantly, why.